Path: ISSHA » Welcome to ISSHA » Harmful Algae Links » Phycotoxins » Okadaic acid, DTX (DSP)

Diarrhetic Shellfish Poisoning and Organisms

New additions are indicated by an asterisk (*). Last update: 26 March 2013.

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Diarrhetic Shellfish Poisoning: Harmful Algae Website; Woods Hole Oceanographic Institution, Woods Hole, MA, USA

Diarrhoeic Shellfish Poisoning (DSP): Food Safety Watch. Richard Lawley - November 2008

Neurotoxins from Marine Dinoflagellates: A Brief Review: by D.-Z. Wang (2008) Mar. Drugs 6: 349-371; Open Access PDF file (521 KB); discusses DSP

Diarrhetic Shellfish Poisoning: Information from Lora E. Fleming, NIEHS Marine and Freshwater Biomedical Sciences Center, Oceans and Human Health Center at the University of Miami Rosenstiel School, FL, USA

Diarrhetic Shellfish Poison: NOAA, Northwest Science Fisheries Center, Seattle, WA, USA

Diarrheic Shellfish Poisoning: Marine & Freshwater Biomedical Science Center; Oceans and Human Health Center at the University of Miami Rosenstiel School, Miami, FL, USA

DSP: University of Miami NIEHS Marine and Freshwater Biomedical Sciences Center

Harmful algal blooms species in thin layers (HABIT): EU project to study Dinophysis in thin layers; pdf file of poster on the project; National University of Ireland, Galway, University Road, Galway, Ireland

Description of DSP Toxins: FAO Food and Nutrition Papers. Note: this section includes pectenotoxins and yessotoxins, but these are incorrectly grouped with the DSP toxins; also, the structure of DTX2 is incorrect (it was revised in 2007; see the Larsen et al. 2007 paper, below: DOI 10.1021/tx700016m)

Larsen, K., D. Petersen, A.L. Wilkins, I.A. Samdal, M. Sandvik, T. Rundberget, D. Goldstone, V. Arcus, P. Hovgaard, F. Rise, N. Rehmann, P. Hess, and C.O. Miles. 2007. Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and is consequences for binding to protein phosphatase. Chem. Res. Toxicol. 20: 868-875. (Publisher's abstract)

Binding of DSP toxins to Protein Phosphatase: QuickTime movie of how OA, DTX1 and DTX2 bind to PP2A. Link to above paper in Chem. Res. Toxicol., 2007, 20: 868–875, DOI 10.1021/tx700016m

Huhn, J., P.D. Jeffrey, K. Larsen, T. Rundberget, F. Rise, N.R. Cox, V. Arcus, Y. Shi, and C.O. Miles. 2009. A structural basis for the reduced toxicity of dinophysistoxin-2. Chem. Res. Toxicol. 22: 1782-1786. (Publisher's abstract)

EFSA advice on the Okadaic Acid and Analogues: European Food Safety Authority. PDF files of the Summary and of the Opinion

Dinophysis spp. PCR detection Kit: DIATHEVA, Fano, Italy

DSP Toxin Certified Reference Materials: Certified Rerence Materials (CRMs) program, NRC, Halifax, NS, Canada

* MaxSignal® Okadaic Acid (DSP) ELISA Test Kit A competitive enzyme immunoassay for the quantitative analysis of okadaic acid in mussels and water samples. Bioo Scientific Corp.(Austin, TX, USA)

Okadaic Acid (DSP) ELISA Test Kit: Sold by Abraxis (Warminster, PA, USA)

Rapid test for DSP: Sold by Jellett Rapid Testing Ltd. (Chester Basin, Nova Scotia, Canada)

ELISA kit for quantitation of Okadaic Acid: Sold by Erfa Biotech (Val-Morin, Quebec, Canada). The company also produces Mouse monoclonal antibody to okadaic acid and Mouse syngeneic monoclonal anti-idiotypic antibody to okadaic acid

Okadaic Acid (DSP) ELISA test kit: Sold by Biosense Laboratories AS (Bergen, Norway)

Okadaic Acid (DSP) ELISA Test Kit: Sold by Ancon Biotech (Guangzhou, China)


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